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Slice of macro-friendly high-protein lasagna layered with lean ground meat, spinach, ricotta, and marinara on a white plate.

High-Protein Meal Prep Lasagna – Macro-Friendly, Meal Prep Comfort Food with 42g Protein Per Slice

Molly
This High-Protein Meal Prep Lasagna is the ultimate macro-friendly comfort food. Each hearty slice delivers 42g of protein and is layered with lean ground beef, sautéed spinach, protein-packed marinara, and melty mozzarella—all baked into a pasta dish that’s perfect for weekly meal prep. Ideal for clean eating, post-workout fuel, or a satisfying dinner that keeps you on track with your nutrition goals.
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Prep Time 20 minutes
Cook Time 45 minutes
Total Time 1 hour 5 minutes
Course Dinner, Meal Prep
Cuisine American, Healthy
Servings 8 slices
Calories 385 kcal

Ingredients
  

  • 1.5 lb lean ground turkey 93%
  • 8 high-protein lasagna noodles like Barilla Protein+
  • 1.5 cups low-fat cottage cheese
  • 1 large egg
  • 1.5 cups shredded part-skim mozzarella
  • ⅓ cup grated Parmesan
  • 24 oz no-sugar marinara sauce
  • 1 yellow onion diced
  • 3 cloves garlic minced
  • 1 tbsp olive oil
  • 1 tsp dried basil
  • 1 tsp oregano
  • ¼ tsp crushed red pepper
  • Salt and pepper to taste

Instructions
 

  • Step 1: Cook the Meat Sauce
    Heat olive oil in a large skillet. Sauté onion and garlic, then add turkey. Season with basil, oregano, pepper flakes, salt, and pepper. Cook until browned. Stir in marinara sauce and simmer for 10 minutes.
  • Step 2: Mix the Cheese Layer
    In a bowl, combine cottage cheese, egg, half the mozzarella, and a pinch of salt and pepper.
  • Step 3: Assemble the Lasagna
    Preheat oven to 375°F. In a 9×13 baking dish, spread a layer of sauce. Add noodles, half the cheese mixture, more sauce, and repeat. Finish with mozzarella and Parmesan on top.
  • Step 4: Bake
    Cover with foil and bake for 25 minutes. Uncover and bake 20 more minutes until bubbly and golden. Let rest 10–15 minutes before slicing.

Notes

Secret Tips for a Next-Level High-Protein Meal Prep Lasagna

1. Use Cottage Cheese for Extra Protein: Swap traditional ricotta with low-fat cottage cheese—it’s creamier, higher in protein, and blends beautifully with herbs for a lighter, fluffier texture.
2. Add Egg Whites to the Cheese Mixture: Mixing in a few tablespoons of liquid egg whites into your cheese layer boosts the protein content and gives the lasagna structure without extra fat.
3. Use Chickpea or Lentil Lasagna Sheets: Replace standard pasta with chickpea or lentil-based lasagna noodles to sneak in even more protein and fiber while keeping it gluten-free if needed.
4. Double the Greens: Add layers of sautéed spinach, kale, or even zucchini ribbons between your meat and cheese layers to enhance micronutrient density and stretch each slice further.
5. Let It Rest Before Slicing: After baking, allow the lasagna to rest for 15–20 minutes. This keeps the layers intact when slicing for meal prep and prevents watery servings.
6. Portion Before Storing: Cut the entire pan into individual slices immediately after cooling. Wrap or store each in airtight containers for grab-and-go meals that reheat beautifully.
7. Boost Marinara with Protein: Blend your marinara with a scoop of unflavored collagen peptides or mix in some puréed white beans—it thickens the sauce while secretly upping protein per bite.
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